Drew Barrymore Chloe (voice) Piper Perabo Rachel Ashe Lynn Andy García Delgado (voice) George Lopez Papi (voice) Paul Rodríguez Chico (voice) Plácido Domingo Monte (voice) Edward James Olmos Diablo (voice) Loretta Devine Delta (voice) Jamie Lee Curtis Aunt Viv Luis Guzmán Chucho (voice) Eddie 'Piolin' Sotelo Rafa (voice) Grey DeLisle Mother Dog (voice) Manolo Cardona Sam Cortez Leslie Mann Bimini (uncredited) Cheech Marin Manuel (voice) Michael Urie Sebastian (voice) José María Yázpik Vasquez Maury Sterling Rafferty Jesús Ochoa Officer Ramirez Eugenio Derbez Store Owner Omar Leyva Ranger Ali Hillis Angela Marguerite Moreau Blair Nick Zano Bryan Gina Gallego Shelter Director Alberto Reyes Bellman Brandon Keener Waiter Sal Lopez Ring Announcer Jack Plotnick Dog Nanny James P. Bennett Bull Fighter (uncredited) Yacine Belhousse Additional Voices (voice) Amelle Chahbi Additional Voices (voice) Fabrice Eboué Additional Voices (voice) Thomas Ngijol Additional Voices (voice) Frédéric Chau Additional Voices (voice) Wahid Bouzidi Additional Voices (voice) Jamel Debbouze Additional Voices (voice) Blanche Gardin Additional Voices (voice)