Comienza a correrse la voz por las calles de Nueva Orleans de una misteriosa pastilla nueva que le confiere superpoderes únicos a cada persona que la consume. ¿La trampa? No sabes qué puede pasar hasta que la tomas... Algunos adquieren una piel a prueba de balas, invisibilidad y fuerza sobrehumana, mientras que otros padecen una reacción más letal. Con la llegada de la pastilla, la tasa de delitos de la ciudad escala a niveles peligrosos, por lo que un policía local (Joseph Gordon-Levitt) se une a una traficante de drogas adolescente (Dominique Fishback) y a un exsoldado motivado por un plan de venganza secreto (Jamie Foxx) para enfrentar con poder al poder. Tanto es así, que se arriesgan a tomar la pastilla con el objetivo de encontrar y detener al grupo responsable de su elaboración.
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