Tobey Maguire Spider-Man / Peter Parker Kirsten Dunst Mary Jane Watson James Franco New Goblin / Harry Osborn Thomas Haden Church Sandman / Flint Marko Topher Grace Venom / Eddie Brock Bryce Dallas Howard Gwen Stacy Rosemary Harris May Parker J.K. Simmons J. Jonah Jameson James Cromwell Captain Stacey Dylan Baker Dr. Curt Connors Theresa Russell Emma Marko Bill Nunn Joseph 'Robbie' Robertson Bruce Campbell Maître D' Elizabeth Banks Miss Brant Ted Raimi Hoffman Perla Haney-Jardine Penny Marko Willem Dafoe Green Goblin / Norman Osborn Cliff Robertson Ben Parker Elya Baskin Mr. Ditkovitch Mageina Tovah Ursula John Paxton Houseman Becky Ann Baker Mrs. Stacy Stan Lee Man in Times Square Michael Papajohn Dennis Carradine / Carjacker Joe Manganiello Flash Thompson Lucy Gordon Jennifer Dugan Steve Valentine Photographer Tim Maculan Play Director Marc Vann Play Producer Joe Bays Jazz Club Manager Gregg Daniel Precinct Detective Rogelio T. Ramos Emergency Room Doctor Timothy Patrick Quill Crane Operator Kathryn Bryding Woman Outside Theater Joe Virzi Police Detective Bill E. Rogers New Jersey State Policeman April Parker Jones Test Site Technician Edward Padilla Test Site Technician Robert Curtis Brown Test Site Technician Paul Terrell Clayton Test Site Technician Carolyn Neff Test Site Technician Christina Cindrich Test Site Technician Sonya Maddox ICU Nurse Andre B. Blake Crane Disaster Radio Policeman Emilio Rivera Policeman at Sand Truck Keith Woulard Policeman at Sand Truck Reynaldo Gallegos Armored Car Driver Dean Edwards Newsstand Patron Margaret Laney Newsstand Patron Toni Wynne Congratulatory Woman at Daily Bugle Tanya Bond Jazz Club Waitress Mark Kubr Jazz Club Bouncer Emma Raimi Girl With Camera Dan Callahan Jazz Club Musician Ron King Jazz Club Musician Frank Anello NYPD Officer (uncredited) Anya Avaeva Model (uncredited) David Backus Bucket Boy (uncredited) Amy V. Dewhurst Columbia Grad Student (uncredited) Logan Fry Automobile Driver (uncredited) Andrew James Jones Jazz Club Bouncer (uncredited) Natalie Jones Girl at Key Ceremony (uncredited) Bernadette Lords British Publicist (uncredited) Natalie McNeil Girl Screaming in Camaro (uncredited) Martha Millan Oscorp Receptionist (uncredited) Jen Oda Beautiful Girl (uncredited) Anjelia Pelay Beautiful Woman (uncredited) Vanessa Reseland Beautiful Woman (uncredited) La Rivers Beautiful Woman (uncredited) Vanessa Ross Sandman Victim (uncredited) Shade Rupe City Hall Cheerer (uncredited) Jennifer Sparks Jazz Club Waitress (uncredited) Christopher Stadulis NY Firefighter (uncredited) Evelyn Vaccaro Beautiful Woman (uncredited) Sincerely A. Ward Model (uncredited) Jennifer Weston ER Nurse (uncredited) Samantha Ressler Girl at the Final Battle Craig 'Radioman' Castaldo Radioman (uncredited)