Stephen Fry Leonardo da Vinci (voice) Daisy Ridley Princess Marguerite (voice) Marion Cotillard Louise de Savoy (voice) Matt Berry Pope Leo XI (voice) Natalie Palamides Pierre Nepveu / Antonio de Beatis (voice) Jim Capobianco Cardinal of Aragon (voice) Gauthier Battoue Francis I of France (voice) John Gilkey Gravedigger John / Giuliano (voice)